Urine matrix metalloproteinase-7 and risk of kidney disease progression and mortality in type 2 diabetes.

ABSTRACT:

Aims

The renin-angiotensin-aldosterone system (RAAS), bone morphogenetic protein (BMP) and WNT pathways are dysregulated in diabetic kidney disease (DKD). Urine excretion of angiotensinogen, gremlin-1 and matrix metalloproteinase-7 (MMP-7), components of the RAAS, BMP and WNT pathways, respectively, is increased in DKD. We asked if this increase is associated with subsequent progression to end-stage renal disease (ESRD) or death.

Methods

Using time-to-event analyses, we examined the association of baseline urine concentration of these proteins with progression to ESRD or death in a predominantly Mexican-American cohort with type 2 diabetes and proteinuric DKD (n=141).

Results

Progression to ESRD occurred for 38 participants over a median follow-up of 3.0years; 39 part

SUBMITTER: Afkarian M 

PROVIDER: S-EPMC5389898 | biostudies-literature | 2015 Nov-Dec

REPOSITORIES: biostudies-literature