Transcriptional profiling of mitochondria associated genes in prefrontal cortex of subjects with major depressive disorder.

ABSTRACT:

Objectives

Recent evidences suggest that mitochondrial dysfunction maybe involved in the pathophysiology of major depressive disorder (MDD); however, the role of mitochondrial genes in this disorder has not been studied systematically. In the present study, we profiled expression of mitochondrial genes in dorsolateral prefrontal cortex (dlPFC) of MDD and non-psychiatric control subjects.

Methods

Human mitochondrial RT² profile PCR array plates were used to examine differentially expressed genes in dlPFC of 11 MDD and 11 control subjects. Differentially expressed genes were validated independently by qRT-PCR. Biological relevance of differentially expressed genes was analysed by gene ontology (GO) and ingenuity pathways analysis (IPA).

Results

We found that

SUBMITTER: Wang Q 

PROVIDER: S-EPMC5389940 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature