DNA Methylation Profiles of Blood Cells Are Distinct between Early-Onset Obese and Control Individuals.

ABSTRACT: Obesity is a highly prevalent, chronic disorder that has been increasing in incidence in young patients. Both epigenetic and genetic aberrations may play a role in the pathogenesis of obesity. Therefore, in-depth epigenomic and genomic analyses will advance our understanding of the detailed molecular mechanisms underlying obesity and aid in the selection of potential biomarkers for obesity in youth. Here, we performed microarray-based DNA methylation and gene expression profiling of peripheral white blood cells obtained from six young, obese individuals and six healthy controls. We observed that the hierarchical clustering of DNA methylation, but not gene expression, clearly segregates the obese individuals from the controls, suggesting that the metabolic disturbance that occurs as a resul

SUBMITTER: Rhee JK 

PROVIDER: S-EPMC5389946 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature