Hyperphosphorylated tau causes reduced hippocampal CA1 excitability by relocating the axon initial segment.

ABSTRACT: Hyperphosphorylated tau has a critical role in tauopathies such as Alzheimer's disease and frontotemporal dementia, impairing neuronal function and eventually leading to neurodegeneration. A critical role for tau is supported by studies in transgenic mouse models that express the P301L tau mutation found in cases of familial frontotemporal dementia, with the accumulation of hyperphosphorylated tau in the hippocampus causing reductions in hippocampal long-term potentiation and impairments in spatial learning and memory. However, what has remained unexplored is the role of hyperphosphorylated tau in reducing neuronal excitability. Here, we show in two complementary P301L tau transgenic mouse models that hyperphosphorylated tau induces a more depolarized threshold for action potential initiat

SUBMITTER: Hatch RJ 

PROVIDER: S-EPMC5389999 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature