Kainic Acid Induces mTORC1-Dependent Expression of Elmo1 in Hippocampal Neurons.

ABSTRACT: Epileptogenesis is a process triggered by initial environmental or genetic factors that result in epilepsy and may continue during disease progression. Important parts of this process include changes in transcriptome and the pathological rewiring of neuronal circuits that involves changes in neuronal morphology. Mammalian/mechanistic target of rapamycin (mTOR) is upregulated by proconvulsive drugs, e.g., kainic acid, and is needed for progression of epileptogenesis, but molecular aspects of its contribution are not fully understood. Since mTOR can modulate transcription, we tested if rapamycin, an mTOR complex 1 inhibitor, affects kainic acid-evoked transcriptome changes. Using microarray technology, we showed that rapamycin inhibits the kainic acid-induced expression of multiple functiona

SUBMITTER: Blazejczyk M 

PROVIDER: S-EPMC5390005 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature