Renal Function and Death in Older Women: Which eGFR Formula Should We Use?

ABSTRACT: Background. The Berlin Initiative Study (BIS) eGFR equations were developed specifically for aged populations, but their predictive validity compared to standard formulae is unknown in older women. Methods. In a prospective study of 1289 community-dwelling older women (mean age 79.5 years), we compared the performance of the BIS1 SCr-based equation to the CKD-EPI_cr and the BIS2 SCr- and Scysc-based equation to the CKD-EPI_cr,cysc to predict cardiovascular and all-cause mortality. Results. Prevalence of specific eGFR category (i.e., ≥75, 60-74, 45-59, and <45) according to eGFR equation was 12.3%, 38.4%, 37.3%, and 12.0% for BIS1; 48.3%, 27.8%, 16.2%, and 7.8% for CKD-EPI_cr; 14.1%, 38.6%, 37.6%, and 9.6% for BIS2; and 33.5%, 33.4%, 22.0%,

SUBMITTER: Canales MT 

PROVIDER: S-EPMC5390547 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature