Dataset Information

Changes in metabolic risk factors over 10 years and their associations with late-life cognitive performance: The Multi-Ethnic Study of Atherosclerosis.

ABSTRACT:

Background

We examined whether changes in metabolic factors over 10 years were associated with cognitive performance.

Methods

Participants from the Multi-Ethnic Study of Atherosclerosis were followed since baseline (2000-2002) with five clinical examinations. At exam 5 (2010-2012), they received a short cognitive battery (Cognitive Abilities Screening Instrument [CASI], Digit Symbol Coding [DSC], and Digit Span [DS]). We examined associations between baseline metabolic factors and their changes over time before cognitive testing.

Results

Among 4392 participants, baseline metabolic disorders (fasting glucose, systolic and diastolic blood pressures) were significantly associated with poorer CASI, DSC, and DS scores measured 10 years later. Increases in blood pressure were associated with lower cognitive performance. Results did not differ by race/ethnicity and were stronger among those without the APOE ε4 allele.

Conclusions

Cognitive performance was associated with antecedent abnormalities in glucose metabolism and blood pressure increases. Findings appeared stronger among APOE ε4-negative participants.

SUBMITTER: Hughes TM

PROVIDER: S-EPMC5390661 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature

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Publications

Changes in metabolic risk factors over 10 years and their associations with late-life cognitive performance: The Multi-Ethnic Study of Atherosclerosis.

Hughes Timothy M TM Craft Suzanne S Baker Laura D LD Espeland Mark A MA Rapp Stephen R SR Sink Kaycee M KM Bertoni Alain G AG Burke Gregory L GL Gottesman Rebecca F RF Michos Erin D ED Luchsinger José A JA Fitzpatrick Annette L AL Hayden Kathleen M KM

Alzheimer's & dementia (Amsterdam, Netherlands) 20170331

<h4>Background</h4>We examined whether changes in metabolic factors over 10 years were associated with cognitive performance.<h4>Methods</h4>Participants from the Multi-Ethnic Study of Atherosclerosis were followed since baseline (2000-2002) with five clinical examinations. At exam 5 (2010-2012), they received a short cognitive battery (Cognitive Abilities Screening Instrument [CASI], Digit Symbol Coding [DSC], and Digit Span [DS]). We examined associations between baseline metabolic factors and ...[more]

PMID: 28435852

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Project description:Background Mobile health (mHealth) has an emerging role in the prevention of cardiovascular disease. This study evaluated possible inequities in mHealth access in older adults. Methods and Results mHealth access was assessed from 2019 to 2020 in MESA (Multi-Ethnic Study of Atherosclerosis) telephone surveys of 2796 participants aged 62 to 102 years. A multivariable logistic regression model adjusted for general health status assessed associations of mHealth access measures with relevant demographic, socioeconomic, and cognitive characteristics. There were lower odds of all access measures with older age (odds ratios [ORs], 0.37-0.59 per 10 years) and annual income <$50 000 (versus ≥$50 000 ORs, 0.55-0.62), and higher odds with higher Cognitive Abilities Screening Instrument Score (ORs, 1.22-1.29 per 5 points). Men (versus women) had higher odds of internet access (OR, 1.32 [95% CI,1.05-1.66]) and computing device ownership (OR, 1.31 [95% CI, 1.05-1.63]) but lower fitness tracker ownership odds (OR, 0.70 [95% CI, 0.49-0.89]). For internet access and computing device ownership, we saw lower odds for Hispanic participants (versus White participants OR, 0.61 [95% CI, 0.44-0.85]; OR, 0.69 [95% CI, 0.50-0.95]) and less than a high school education (versus bachelor's degree or higher OR, 0.27 [95% CI, 0.18-0.40]; OR, 0.32 [95% CI, 0.28-0.62]). For internet access, lower odds were seen for Black participants (versus White participants OR, 0.64 [95% CI, 0.47-0.86]) and other health insurance (versus health maintenance organization/private OR, 0.59 [95% CI, 0.47-0.74]). Chinese participants (versus White participants) had lower internet access odds (OR, 0.63 [95% CI, 0.44-0.91]) but higher computing device ownership odds (OR, 1.87 [95% CI, 1.28-2.77]). Conclusions Among older-age adults, mHealth access varied by major demographic, socioeconomic, and cognitive characteristics, suggesting a digital divide. Novel mHealth interventions should consider individual access barriers. Registration URL: https://www.clinicaltrials.gov/; Unique identifier: NCT00005487.

Dataset Information

Changes in metabolic risk factors over 10 years and their associations with late-life cognitive performance: The Multi-Ethnic Study of Atherosclerosis.

Background

Methods

Results

Conclusions

Publications

Changes in metabolic risk factors over 10 years and their associations with late-life cognitive performance: The Multi-Ethnic Study of Atherosclerosis.

Similar Datasets

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