Spatiotemporal dissociation of brain activity underlying threat and reward in social anxiety disorder.

ABSTRACT: Social anxiety disorder (SAD) involves abnormalities in social motivation, which may be independent of well-documented differences in fear and arousal systems. Yet, the neurobiology underlying motivational difficulties in SAD is not well understood. The aim of the current study was to spatiotemporally dissociate reward circuitry dysfunction from alterations in fear and arousal-related neural activity during anticipation and notification of social and non-social reward and punishment. During fMRI acquisition, non-depressed adults with social anxiety disorder (SAD; N = 21) and age-, sex- and IQ-matched control subjects (N = 22) completed eight runs of an incentive delay task, alternating between social and monetary outcomes and interleaved in alternating order between gain and loss outcomes.

SUBMITTER: A Richey J 

PROVIDER: S-EPMC5390704 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature