Intranasal oxytocin increases neural responses to social reward in post-traumatic stress disorder.

ABSTRACT: Therapeutic alliance and perceived social support are important predictors of treatment response for post-traumatic stress disorder (PTSD). Intranasal oxytocin administration may enhance treatment response by increasing sensitivity for social reward and thereby therapeutic alliance and perceived social support. As a first step to investigate this therapeutical potential, we investigated whether intranasal oxytocin enhances neural sensitivity to social reward in PTSD patients. Male and female police officers with (n = 35) and without PTSD (n = 37) were included in a double-blind, randomized, placebo-controlled cross-over fMRI study. After intranasal oxytocin (40 IU) and placebo administration, a social incentive delay task was conducted to investigate neural responses during social reward a

SUBMITTER: Nawijn L 

PROVIDER: S-EPMC5390752 | biostudies-literature | 2017 Feb

REPOSITORIES: biostudies-literature