Ontology highlight
ABSTRACT:
SUBMITTER: Li M
PROVIDER: S-EPMC5390777 | biostudies-literature | 2017 Jan
REPOSITORIES: biostudies-literature
Human mutation 20161003 1
Alternative splicing (AS) is a closely regulated process that allows a single gene to encode multiple protein isoforms, thereby contributing to the diversity of the proteome. Dysregulation of the splicing process has been found to be associated with many inherited diseases. However, among the pathogenic AS events, there are numerous "passenger" events whose inclusion or exclusion does not lead to significant changes with respect to protein function. In this study, we evaluate the secondary and t ...[more]