Brain serotonin 4 receptor binding is inversely associated with verbal memory recall.

ABSTRACT:

Background

We have previously identified an inverse relationship between cerebral serotonin 4 receptor (5-HT ₄R) binding and nonaffective episodic memory in healthy individuals. Here, we investigate in a novel sample if the association is related to affective components of memory, by examining the association between cerebral 5-HT ₄R binding and affective verbal memory recall.

Methods

Twenty-four healthy volunteers were scanned with the 5-HT ₄R radioligand [¹¹C]SB207145 and positron emission tomography, and were tested with the Verbal Affective Memory Test-24. The association between 5-HT ₄R binding and affective verbal memory was evaluated using a linear latent variable structural equation model.

Results

We obser

SUBMITTER: Stenbæk DS 

PROVIDER: S-EPMC5390847 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature