Defective enamel and bone development in sodium-dependent citrate transporter (NaCT) Slc13a5 deficient mice.

ABSTRACT: There has been growing recognition of the essential roles of citrate in biomechanical properties of mineralized tissues, including teeth and bone. However, the sources of citrate in these tissues have not been well defined, and the contribution of citrate to the regulation of odontogenesis and osteogenesis has not been examined. Here, tooth and bone phenotypes were examined in sodium-dependent citrate transporter (NaCT) Slc13a5 deficient C57BL/6 mice at 13 and 32 weeks of age. Slc13a5 deficiency led to defective tooth development, characterized by absence of mature enamel, formation of aberrant enamel matrix, and dysplasia and hyperplasia of the enamel organ epithelium that progressed with age. These abnormalities were associated with fragile teeth with a possible predisposition to tooth a

SUBMITTER: Irizarry AR 

PROVIDER: S-EPMC5391028 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature