DNA methylation and expression of stress related genes in PBMC of MDD patients with and without serious suicidal ideation.

ABSTRACT: Stress plays an important role in major depressive disorder (MDD) and is one of the state dependent factors in suicidal behavior. A dysfunctional hypothalamic-pituitary-adrenal axis is a common feature in this disorder. The involvement of environmental factors has added additional complexity to understanding depression or suicidal behavior. In this regard, epigenetic regulation has been considered a mechanistic interface between environmental stress stimuli and altered functioning of underlying gene network that may increase susceptibility to depression or suicidal behavior. The present study examined whether epigenetic modifications of stress related genes are associated with MDD and whether there are differences in these epigenetic marks between depressed individuals with and without ser

SUBMITTER: Roy B 

PROVIDER: S-EPMC5391149 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature