Association of genetic variations with pharmacokinetics and lipid-lowering response to atorvastatin in healthy Korean subjects.

ABSTRACT:

Background

Statins are effective agents in the primary and secondary prevention of cardiovascular disease, but treatment response to statins varies among individuals. We analyzed multiple genetic polymorphisms and assessed pharmacokinetic and lipid-lowering responses after atorvastatin 80 mg treatment in healthy Korean individuals.

Methods

Atorvastatin 80 mg was given to 50 healthy Korean male volunteers. Blood samples were collected to measure plasma atorvastatin and lipid concentrations up to 48 hours after atorvastatin administration. Subjects were genotyped for 1,936 drug metabolism and transporter genetic polymorphisms using the Affymetrix DMET plus array.

Results

The pharmacokinetics and lipid-lowering effect of atorvastatin showed remarkable interindividual var

SUBMITTER: Woo HI 

PROVIDER: S-EPMC5391214 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature