Amyloid and tau PET demonstrate region-specific associations in normal older people.

ABSTRACT: β-amyloid (Aβ) and tau pathology become increasingly prevalent with age, however, the spatial relationship between the two pathologies remains unknown. We examined local (same region) and non-local (different region) associations between these 2 aggregated proteins in 46 normal older adults using [¹⁸F]AV-1451 (for tau) and [¹¹C]PiB (for Aβ) positron emission tomography (PET) and 1.5T magnetic resonance imaging (MRI) images. While local voxelwise analyses showed associations between PiB and AV-1451 tracer largely in the temporal lobes, k-means clustering revealed that some of these associations were driven by regions with low tracer retention. We followed this up with a whole-brain region-by-region (local and non-local) partial correlational analysis. We calculated eac

SUBMITTER: Lockhart SN 

PROVIDER: S-EPMC5391247 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature