Comprehensive Analysis of Established Dyslipidemia-Associated Loci in the Diabetes Prevention Program.

ABSTRACT:

Background

We assessed whether 234 established dyslipidemia-associated loci modify the effects of metformin treatment and lifestyle intervention (versus placebo control) on lipid and lipid subfraction levels in the Diabetes Prevention Program randomized controlled trial.

Methods and results

We tested gene treatment interactions in relation to baseline-adjusted follow-up blood lipid concentrations (high-density lipoprotein [HDL] and low-density lipoprotein-cholesterol, total cholesterol, and triglycerides) and lipoprotein subfraction particle concentrations and size in 2993 participants with pre-diabetes. Of the previously reported single-nucleotide polymorphism associations, 32.5% replicated at P<0.05 with baseline lipid traits. Trait-specific genetic risk scores were robust

SUBMITTER: Varga TV 

PROVIDER: S-EPMC5391253 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature