Impaired Hydrogen Sulfide-Mediated Vasodilation Contributes to Microvascular Endothelial Dysfunction in Hypertensive Adults.

ABSTRACT: Reductions in hydrogen sulfide (H₂S) production have been implicated in the pathogenesis of vascular dysfunction in animal models of hypertension; however, no studies have examined a functional role for H₂S in contributing to microvascular dysfunction in hypertensive (HTN) adults. We hypothesized that endogenous production of H₂S would be reduced, impaired endothelium-dependent vasodilation would be mediated by reductions in H₂S-dependent vasodilation, and vascular responsiveness to exogenous H₂S (sodium sulfide) would be attenuated in HTN compared to normotensive adults. Fifteen normotensive (51±2 years; blood pressure, 116±3/76±3 mm Hg) and 14 HTN adults (57±2 years; blood pressure 140±3/89±2 mm Hg) participated. H₂S biosy

SUBMITTER: Greaney JL 

PROVIDER: S-EPMC5391285 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature