The nasal methylome and childhood atopic asthma.

ABSTRACT:

Background

Given the strong environmental influence on both epigenetic marks and allergic asthma in children, the epigenetic alterations in respiratory epithelia might provide insight into allergic asthma.

Objective

We sought to identify DNA methylation and gene expression changes associated with childhood allergic persistent asthma.

Methods

We compared genomic DNA methylation patterns and gene expression in African American children with persistent atopic asthma (n = 36) versus healthy control subjects (n = 36). Results were validated in an independent population of asthmatic children (n = 30) by using a shared healthy control population (n = 36) and in an independent population of white adult atopic asthmatic patients (n = 12) and control subjects (n = 12).

Resul

SUBMITTER: Yang IV 

PROVIDER: S-EPMC5391298 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature