A hybrid multibreath wash-in wash-out lung function quantification scheme in human subjects using hyperpolarized ³ He MRI for simultaneous assessment of specific ventilation, alveolar oxygen tension, oxygen uptake, and air trapping.

ABSTRACT:

Purpose

To present a method for simultaneous acquisition of alveolar oxygen tension (P_A O₂ ), specific ventilation (SV), and apparent diffusion coefficient (ADC) of hyperpolarized (HP) gas in the human lung, allowing reinterpretation of the P_A O₂ and SV maps to produce a map of oxygen uptake (R).

Method

An imaging scheme was designed with a series of identical normoxic HP gas wash-in breaths to measure ADC, SV, P_A O₂ , and R in less than 2 min. Signal dynamics were fit to an iterative recursive model that regionally solved for these parameters. This measurement was successfully performed in 12 subjects classified in three healthy, smoker, and chronic obstructive pulmonary disease (COPD) cohorts.

Results

SUBMITTER: Hamedani H 

PROVIDER: S-EPMC5391315 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature