Understanding the Kinetics of Protein-Nanoparticle Corona Formation.

ABSTRACT: When a pristine nanoparticle (NP) encounters a biological fluid, biomolecules spontaneously form adsorption layers around the NP, called "protein corona". The corona composition depends on the time-dependent environmental conditions and determines the NP's fate within living organisms. Understanding how the corona evolves is fundamental in nanotoxicology as well as medical applications. However, the process of corona formation is challenging due to the large number of molecules involved and to the large span of relevant time scales ranging from 100 μs, hard to probe in experiments, to hours, out of reach of all-atoms simulations. Here we combine experiments, simulations, and theory to study (i) the corona kinetics (over 10^-3-10³ s) and (ii) its final composition for s

SUBMITTER: Vilanova O 

PROVIDER: S-EPMC5391497 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature