DNA methylation profiling in peripheral lung tissues of smokers and patients with COPD.

ABSTRACT:

Background

Epigenetics changes have been shown to be affected by cigarette smoking. Cigarette smoke (CS)-mediated DNA methylation can potentially affect several cellular and pathophysiological processes, acute exacerbations, and comorbidity in the lungs of patients with chronic obstructive pulmonary disease (COPD). We sought to determine whether genome-wide lung DNA methylation profiles of smokers and patients with COPD were significantly different from non-smokers. We isolated DNA from parenchymal lung tissues of patients including eight lifelong non-smokers, eight current smokers, and eight patients with COPD and analyzed the samples using Illumina's Infinium HumanMethylation450 BeadChip.

Results

Our data revealed that the differentially methylated genes were related to to

SUBMITTER: Sundar IK 

PROVIDER: S-EPMC5391602 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature