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Primary, Adaptive, and Acquired Resistance to Cancer Immunotherapy.

ABSTRACT: Cancer immunotherapy can induce long lasting responses in patients with metastatic cancers of a wide range of histologies. Broadening the clinical applicability of these treatments requires an improved understanding of the mechanisms limiting cancer immunotherapy. The interactions between the immune system and cancer cells are continuous, dynamic, and evolving from the initial establishment of a cancer cell to the development of metastatic disease, which is dependent on immune evasion. As the molecular mechanisms of resistance to immunotherapy are elucidated, actionable strategies to prevent or treat them may be derived to improve clinical outcomes for patients.

SUBMITTER: Sharma P 

PROVIDER: S-EPMC5391692 | biostudies-literature | 2017 Feb

REPOSITORIES: biostudies-literature

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Primary, Adaptive, and Acquired Resistance to Cancer Immunotherapy.

Sharma Padmanee P   Hu-Lieskovan Siwen S   Wargo Jennifer A JA   Ribas Antoni A  

Cell 20170201 4

Cancer immunotherapy can induce long lasting responses in patients with metastatic cancers of a wide range of histologies. Broadening the clinical applicability of these treatments requires an improved understanding of the mechanisms limiting cancer immunotherapy. The interactions between the immune system and cancer cells are continuous, dynamic, and evolving from the initial establishment of a cancer cell to the development of metastatic disease, which is dependent on immune evasion. As the mo  ...[more]

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