MeSHDD: Literature-based drug-drug similarity for drug repositioning.

ABSTRACT:

Objective

Drug repositioning is a promising methodology for reducing the cost and duration of the drug discovery pipeline. We sought to develop a computational repositioning method leveraging annotations in the literature, such as Medical Subject Heading (MeSH) terms.

Methods

We developed software to determine significantly co-occurring drug-MeSH term pairs and a method to estimate pair-wise literature-derived distances between drugs.

Results

We found that literature-based drug-drug similarities predicted the number of shared indications across drug-drug pairs. Clustering drugs based on their similarity revealed both known and novel drug indications. We demonstrate the utility of our approach by generating repositioning hypotheses for the commonly used diabetes drug m

SUBMITTER: Brown AS 

PROVIDER: S-EPMC5391732 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature