IL-1β-induced and p38^MAPK-dependent activation of the mitogen-activated protein kinase-activated protein kinase 2 (MK2) in hepatocytes: Signal transduction with robust and concentration-independent signal amplification.

ABSTRACT: The IL-1β induced activation of the p38^MAPK/MAPK-activated protein kinase 2 (MK2) pathway in hepatocytes is important for control of the acute phase response and regulation of liver regeneration. Many aspects of the regulatory relevance of this pathway have been investigated in immune cells in the context of inflammation. However, very little is known about concentration-dependent activation kinetics and signal propagation in hepatocytes and the role of MK2. We established a mathematical model for IL-1β-induced activation of the p38^MAPK/MK2 pathway in hepatocytes that was calibrated to quantitative data on time- and IL-1β concentration-dependent phosphorylation of p38^MAPK and MK2 in primary mouse hepatocytes. This analysis showed that, in hepatocytes, signa

SUBMITTER: Kulawik A 

PROVIDER: S-EPMC5391758 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature