Allostery modulates the beat rate of a cardiac pacemaker.

ABSTRACT: The S672R mutation in heart cell ion channels leads to low heart rates and arrhythmia by an unknown route. A multifaceted NMR analysis now demonstrates that this mutant impacts allosteric coupling in domains inside of the cell to change channel activation, providing a mechanistic explanation for phenotypic outcomes.

SUBMITTER: Tsai CJ 

PROVIDER: S-EPMC5391769 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature