Performance of interferon-γ release assay in the diagnosis of tuberculous lymphadenitis: a meta-analysis.

ABSTRACT:

Background

The diagnostic values of interferon-gamma release assays (IGRA) in tuberculosis (TB) vary a lot with different site of infections, with especially higher sensitivities in chronic forms of TB such as tuberculosis of the lymph node. We conducted a meta-analysis to comprehensively evaluate the overall accuracy of diagnostic IGRA for tuberculous lymphadenitis.

Methods

Pubmed, Web of Science, EMBASE, Wanfang and CNKI databases up to February 17, 2017 were searched to identify published studies. The study quality was evaluated using the QUADAS-2 checklist. The pooled estimates of diagnostic parameters were generated using a bivariate random-effects model and summary receiver operating characteristic (SROC) curves were used to summarize global performance.

Results

SUBMITTER: Liu Q 

PROVIDER: S-EPMC5391793 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature