Structure and physicochemical characterization of a naproxen-picolinamide cocrystal.

ABSTRACT: Naproxen (NPX) is a nonsteroidal anti-inflammatory drug with pain- and fever-relieving properties, currently marketed in the sodium salt form to overcome solubility problems; however, alternative solutions for improving its solubility across all pH values are desirable. NPX is suitable for cocrystal formation, with hydrogen-bonding possibilities via the COOH group. The crystal structure is presented of a 1:1 cocrystal of NPX with picolinamide as a coformer [systematic name: (S)-2-(6-methoxynaphthalen-2-yl)propanoic acid-pyridine-2-carboxamide (1/1), C₁₄H₁₄O₃·C₆H₆N₂O]. The pharmaceutically relevant physical properties were investigated and the intrinsic dissolution rate was found to be essentially the same as that of commerci

SUBMITTER: Kerr HE 

PROVIDER: S-EPMC5391861 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature