Interrogating the topological robustness of gene regulatory circuits by randomization.

ABSTRACT: One of the most important roles of cells is performing their cellular tasks properly for survival. Cells usually achieve robust functionality, for example, cell-fate decision-making and signal transduction, through multiple layers of regulation involving many genes. Despite the combinatorial complexity of gene regulation, its quantitative behavior has been typically studied on the basis of experimentally verified core gene regulatory circuitry, composed of a small set of important elements. It is still unclear how such a core circuit operates in the presence of many other regulatory molecules and in a crowded and noisy cellular environment. Here we report a new computational method, named random circuit perturbation (RACIPE), for interrogating the robust dynamical behavior of a gene regula

SUBMITTER: Huang B 

PROVIDER: S-EPMC5391964 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature