Cis-eQTL-based trans-ethnic meta-analysis reveals novel genes associated with breast cancer risk.

ABSTRACT: Breast cancer is the most common solid organ malignancy and the most frequent cause of cancer death among women worldwide. Previous research has yielded insights into its genetic etiology, but there remains a gap in the understanding of genetic factors that contribute to risk, and particularly in the biological mechanisms by which genetic variation modulates risk. The National Cancer Institute's "Up for a Challenge" (U4C) competition provided an opportunity to further elucidate the genetic basis of the disease. Our group leveraged the seven datasets made available by the U4C organizers and data from the publicly available UK Biobank cohort to examine associations between imputed gene expression and breast cancer risk. In particular, we used reference datasets describing the breast tissue a

SUBMITTER: Hoffman JD 

PROVIDER: S-EPMC5391966 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature