Advances in the pathophysiology and treatment of heart failure with preserved ejection fraction.

ABSTRACT:

Purpose of review

With the failure of multiple trials to identify a successful therapy for heart failure with preserved ejection fraction (HFpEF), attention has shifted to defining specific phenotypes within the HFpEF spectrum in an effort to develop a targeted approach to treatment. Here we summarize the most recent studies investigating the pathophysiology and clinical features of HFpEF, and discuss recent clinical trials in the context of developing treatments that look toward the underlying cause of this disorder.

Recent findings

Advances in basic science and clinical research have further characterized HFpEF, identifying multiple pathophysiological mechanisms that ultimately lead to exercise intolerance and volume overload. The success of small studies focused on specif

SUBMITTER: Tannenbaum S 

PROVIDER: S-EPMC5391977 | biostudies-literature | 2015 May

REPOSITORIES: biostudies-literature