Increased diffusivity in gray matter in recent onset schizophrenia is associated with clinical symptoms and social cognition.

ABSTRACT:

Introduction

Diffusion weighted MRI (dMRI) is a method sensitive to pathological changes affecting tissue microstructure. Most dMRI studies in schizophrenia, however, have focused solely on white matter. There is a possibility, however, that subtle changes in diffusivity exist in gray matter (GM). Accordingly, we investigated diffusivity in GM in patients with recent onset schizophrenia.

Methods

We enrolled 45 patients and 21 age and sex-matched healthy controls. All subjects were evaluated using the short form of the Wechsler Adult Intelligence Scale, the Positive and Negative Syndrome Scale (PANSS), and the video based social cognition scale. DMRI and T1W images were acquired on a 3 Tesla magnet, and mean Fractional Anisotropy (FA), Trace (TR) and volume were calculated fo

SUBMITTER: Lee JS 

PROVIDER: S-EPMC5392041 | biostudies-literature | 2016 Oct

REPOSITORIES: biostudies-literature