A blood RNA signature for tuberculosis disease risk: a prospective cohort study.

ABSTRACT:

Background

Identification of blood biomarkers that prospectively predict progression of Mycobacterium tuberculosis infection to tuberculosis disease might lead to interventions that combat the tuberculosis epidemic. We aimed to assess whether global gene expression measured in whole blood of healthy people allowed identification of prospective signatures of risk of active tuberculosis disease.

Methods

In this prospective cohort study, we followed up healthy, South African adolescents aged 12-18 years from the adolescent cohort study (ACS) who were infected with M tuberculosis for 2 years. We collected blood samples from study participants every 6 months and monitored the adolescents for progression to tuberculosis disease. A prospective signature of risk was derived from who

SUBMITTER: Zak DE 

PROVIDER: S-EPMC5392204 | biostudies-literature | 2016 Jun

REPOSITORIES: biostudies-literature