Is there a dose-dependent effect of genetic susceptibility loci for gastric cancer on prognosis of the patients?

ABSTRACT: Literature suggests that genetic variants associated with increased susceptibility to gastric cancer (GCa) are mostly located in genes involved in carcinogenesis and possibly tumor progression. Therefore, we hypothesize that high genetic susceptibility is also associated with prognosis of the patients. To test this hypothesis, we selected a total of 42 common genetic variants that were reportedly associated with GCa risk with a high level of evidence obtained from either genome-wide association studies (GWASs) or meta-analyses and performed survival analysis of patients used in a case-control analysis. We first used 1115 GCa cases and 1172 cancer-free controls of ethnic Han Chinese to construct a weighted genetic risk score (GRS). Then, we included 633 GCa cases with available clinical inf

SUBMITTER: Cheng L 

PROVIDER: S-EPMC5392341 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature