Biomarker-Based PET Imaging of Diffuse Intrinsic Pontine Glioma in Mouse Models.

ABSTRACT: Diffuse intrinsic pontine glioma (DIPG) is a childhood brainstem tumor with a universally poor prognosis. Here, we characterize a positron emission tomography (PET) probe for imaging DIPG in vivo In human histological tissues, the probes target, PARP1, was highly expressed in DIPG compared to normal brain. PET imaging allowed for the sensitive detection of DIPG in a genetically engineered mouse model, and probe uptake correlated to histologically determined tumor infiltration. Imaging with the sister fluorescence agent revealed that uptake was confined to proliferating, PARP1-expressing cells. Comparison with other imaging technologies revealed remarkable accuracy of our biomarker approach. We subsequently demonstrated that serial imaging of DIPG in mouse models enables monitoring o

SUBMITTER: Kossatz S 

PROVIDER: S-EPMC5392368 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature