Human polyomavirus 6 and 7 are associated with pruritic and dyskeratotic dermatoses.

ABSTRACT:

Background

Human polyomavirus (HPyV)6 and HPyV7 are shed chronically from human skin. HPyV7, but not HPyV6, has been linked to a pruritic skin eruption of immunosuppression.

Objective

We determined whether biopsy specimens showing a characteristic pattern of dyskeratosis and parakeratosis might be associated with polyomavirus infection.

Methods

We screened biopsy specimens showing "peacock plumage" histology by polymerase chain reaction for HPyVs. Cases positive for HPyV6 or HPyV7 were then analyzed by immunohistochemistry, electron microscopy, immunofluorescence, quantitative polymerase chain reaction, and complete sequencing, including unbiased, next-generation sequencing.

Results

We identified 3 additional cases of HPyV6 or HPyV7 skin infections. Expression

SUBMITTER: Nguyen KD 

PROVIDER: S-EPMC5392424 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature