Suction blistering the lesional skin of vitiligo patients reveals useful biomarkers of disease activity.

ABSTRACT:

Background

Vitiligo is an autoimmune disease of the skin with limited treatment options; there is an urgent need to identify and validate biomarkers of disease activity to support vitiligo clinical studies.

Objective

To investigate potential biomarkers of disease activity directly in the skin of vitiligo subjects and healthy subjects.

Methods

Patient skin was sampled via a modified suction-blister technique, allowing for minimally invasive, objective assessment of cytokines and T-cell infiltrates in the interstitial skin fluid. Potential biomarkers were first defined and later validated in separate study groups.

Results

In screening and validation, CD8⁺ T-cell number and C-X-C motif chemokine ligand (CXCL) 9 protein concentration were significantly e

SUBMITTER: Strassner JP 

PROVIDER: S-EPMC5392432 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature