Benzalkonium tolerance genes and outcome in Listeria monocytogenes meningitis.

ABSTRACT:

Objectives

Listeria monocytogenes is a food-borne pathogen that can cause meningitis. The listerial genotype ST6 has been linked to increasing rates of unfavourable outcome over time. We investigated listerial genetic variation and the relation with clinical outcome in meningitis.

Methods

We sequenced 96 isolates from adults with listerial meningitis included in two prospective nationwide cohort studies by whole genome sequencing, and evaluated associations between bacterial genetic variation and clinical outcome. We validated these results by screening listerial genotypes of 445 cerebrospinal fluid and blood isolates from patients over a 30-year period from the Dutch national surveillance cohort.

Results

We identified a bacteriophage, phiLMST6 co-occurring with a nov

SUBMITTER: Kremer PH 

PROVIDER: S-EPMC5392494 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature