RNA-binding Protein Quaking Stabilizes Sirt2 mRNA during Oligodendroglial Differentiation.

ABSTRACT: Myelination is controlled by timely expression of genes involved in the differentiation of oligodendrocyte precursor cells (OPCs) into myelinating oligodendrocytes (OLs). Sirtuin 2 (SIRT2), a NAD⁺-dependent deacetylase, plays a critical role in OL differentiation by promoting both arborization and downstream expression of myelin-specific genes. However, the mechanisms involved in regulating SIRT2 expression during OL development are largely unknown. The RNA-binding protein quaking (QKI) plays an important role in myelination by post-transcriptionally regulating the expression of several myelin specific genes. In quaking viable (qk^v/qk^v ) mutant mice, SIRT2 protein is severely reduced; however, it is not known whether these genes interact to regulate

SUBMITTER: Thangaraj MP 

PROVIDER: S-EPMC5392665 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature