Synaptic Activity Drives a Genomic Program That Promotes a Neuronal Warburg Effect.

ABSTRACT: Synaptic activity drives changes in gene expression to promote long lasting adaptations of neuronal structure and function. One example of such an adaptive response is the buildup of acquired neuroprotection, a synaptic activity- and gene transcription-mediated increase in the resistance of neurons against harmful conditions. A hallmark of acquired neuroprotection is the stabilization of mitochondrial structure and function. We therefore re-examined previously identified sets of synaptic activity-regulated genes to identify genes that are directly linked to mitochondrial function. In mouse and rat primary hippocampal cultures, synaptic activity caused an up-regulation of glycolytic genes and a concomitant down-regulation of genes required for oxidative phosphorylation, mitochondrial biogen

SUBMITTER: Bas-Orth C 

PROVIDER: S-EPMC5392666 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature