Hydrogen Peroxide Triggers a Dual Signaling Axis To Selectively Suppress Activated Human T Lymphocyte Migration.

ABSTRACT: H₂O₂ is an early danger cue required for innate immune cell recruitment to wounds. To date, little is known about whether H₂O₂ is required for the migration of human adaptive immune cells to sites of inflammation. However, oxidative stress is known to impair T cell activity, induce actin stiffness, and inhibit cell polarization. In this study, we show that low oxidative concentrations of H₂O₂ also impede chemokinesis and chemotaxis of previously activated human T cells to CXCL11, but not CXCL10 or CXCL12. We show that this deficiency in migration is due to a reduction in inflammatory chemokine receptor CXCR3 surface expression and cellular activation of lipid phosphatase SHIP-1. We demonstrate that H₂O₂

SUBMITTER: Ball JA 

PROVIDER: S-EPMC5392728 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature