An evolutionarily conserved transcriptional response to viral infection in Caenorhabditis nematodes.

ABSTRACT:

Background

Caenorhabditis elegans is a powerful model organism for probing many biological processes including host-pathogen interactions with bacteria and fungi. The recent identification of nematode viruses that naturally infect C. elegans and Caenorhabditis briggsae provides a unique opportunity to define host-virus interactions in these model hosts.

Results

We analyzed the transcriptional response of pathogen infected C. elegans and C. briggsae by RNA-seq. We identified a total of 320 differentially expressed genes (DEGs) in C. elegans following Orsay virus infection. The DEGs of known function were enriched for ubiquitin ligase related genes; however, the majority of the genes were of unknown function. Interestingly, many DEGs that responded to Orsay virus infection wer

SUBMITTER: Chen K 

PROVIDER: S-EPMC5392922 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature