Large-scale analysis of post-translational modifications in E. coli under glucose-limiting conditions.

ABSTRACT:

Background

Post-translational modification (PTM) of proteins is central to many cellular processes across all domains of life, but despite decades of study and a wealth of genomic and proteomic data the biological function of many PTMs remains unknown. This is especially true for prokaryotic PTM systems, many of which have only recently been recognized and studied in depth. It is increasingly apparent that a deep sampling of abundance across a wide range of environmental stresses, growth conditions, and PTM types, rather than simply cataloging targets for a handful of modifications, is critical to understanding the complex pathways that govern PTM deposition and downstream effects.

Results

We utilized a deeply-sampled dataset of MS/MS proteomic analysis covering 9 timepoints

SUBMITTER: Brown CW 

PROVIDER: S-EPMC5392934 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature