Regulation of Th2 responses by different cell types expressing the interleukin-31 receptor.

ABSTRACT:

Background

Interleukin-31 (IL-31) is a recently identified cytokine produced by Th2 cells that is involved in the development of atopic dermatitis-induced skin inflammation and pruritus. Its receptor, IL-31RA, is expressed by a number of cell types, including epithelial cells, eosinophils, and activated monocytes and macrophages. To date, however, the regulation of Th2 responses by distinct cell types and tissues expressing IL-31RA has not been well studied.

Methods

In this study, Cry j 2, one of the major allergens of Japanese cedar pollen, was administered to IL-31RA-deficient or wild-type (WT) mice via nasal or intraperitoneal injection for induction of specific Th2 responses.

Results

After nasal administration of Cry j 2, IL-31RA-deficient mice showed lower Cry j

SUBMITTER: Saito S 

PROVIDER: S-EPMC5392993 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature