Congenital Cytomegalovirus infection: advances and challenges in diagnosis, prevention and treatment.

ABSTRACT: Cytomegalovirus (CMV) is the most frequent cause of congenital infection worldwide, with an estimated incidence in developing countries of 0.6-0.7% of all live births. The burden of disease related to congenital CMV in substantial, as it is the leading non-genetic cause of sensorineural hearing loss and an important cause of neurodevelopmental disabilities in children. Despite its clinical significance, congenital CMV infection often goes undetected because the majority of infected infants are asymptomatic at birth and screening programs have not been substantially implemented. Other than behavioral measures, effective interventions aimed at the prevention of maternal infection and of mother-to-child transmission are lacking. Due to a convergence of recent advances in both diagnostic and t

SUBMITTER: Marsico C 

PROVIDER: S-EPMC5393008 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature