MiR-424(322)/503 is a breast cancer tumor suppressor whose loss promotes resistance to chemotherapy.

ABSTRACT: The female mammary gland is a very dynamic organ that undergoes continuous tissue remodeling during adulthood. Although it is well established that the number of menstrual cycles and pregnancy (in this case transiently) increase the risk of breast cancer, the reasons are unclear. Growing clinical and experimental evidence indicates that improper involution plays a role in the development of this malignancy. Recently, we described the miR-424(322)/503 cluster as an important regulator of mammary epithelial involution after pregnancy. Here, through the analysis of ∼3000 primary tumors, we show that miR-424(322)/503 is commonly lost in a subset of aggressive breast cancers and describe the genetic aberrations that inactivate its expression. Furthermore, through the use of a knockout mouse mod

SUBMITTER: Rodriguez-Barrueco R 

PROVIDER: S-EPMC5393051 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature