Candidate genes for alcohol dependence: A genetic association study from India.

ABSTRACT:

Background & objectives

Search for candidate genes for alcohol dependence (AD) has been inconsistent and inconclusive. Moreover, most of the research has been confined to a few specific ethnic groups. Hence, the aim of our study was to explore specific candidate genes for AD in north Indian male population.

Methods

In this clinic-based genetic association study, 210 males with AD and 200 controls matched for age, gender and ethnicity were recruited from the clinic and the general population, respectively. Cases were diagnosed with Semi-structured Assessment for Genetics of Alcoholism-II (SSAGA-II). Single-nucleotide polymorphism genotyping was done by real-time quantitative-polymerase chain reaction (PCR) using Taq Man assay (ABI 7500) fast real-time PCR system.

Results</

SUBMITTER: Malhotra S 

PROVIDER: S-EPMC5393079 | biostudies-literature | 2016 Nov

REPOSITORIES: biostudies-literature