Splicing variation of Long-IRBIT determines the target selectivity of IRBIT family proteins.

ABSTRACT: IRBIT [inositol 1,4,5-trisphosphate receptor (IP₃R) binding protein released with inositol 1,4,5-trisphosphate (IP₃)] is a multifunctional protein that regulates several target molecules such as ion channels, transporters, polyadenylation complex, and kinases. Through its interaction with multiple targets, IRBIT contributes to calcium signaling, electrolyte transport, mRNA processing, cell cycle, and neuronal function. However, the regulatory mechanism of IRBIT binding to particular targets is poorly understood. Long-IRBIT is an IRBIT homolog with high homology to IRBIT, except for a unique N-terminal appendage. Long-IRBIT splice variants have different N-terminal sequences and a common C-terminal region, which is involved in multimerization of IRBIT and Long-IRBIT. I

SUBMITTER: Kawaai K 

PROVIDER: S-EPMC5393198 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature