Protectin D1_{n-3 DPA} and resolvin D5_{n-3 DPA} are effectors of intestinal protection.

ABSTRACT: The resolution of inflammation is an active process orchestrated by specialized proresolving lipid mediators (SPM) that limit the host response within the affected tissue; failure of effective resolution may lead to tissue injury. Because persistence of inflammatory signals is a main feature of chronic inflammatory conditions, including inflammatory bowel diseases (IBDs), herein we investigate expression and functions of SPM in intestinal inflammation. Targeted liquid chromatography-tandem mass spectrometry-based metabololipidomics was used to identify SPMs from n-3 polyunsaturated fatty acids in human IBD colon biopsies, quantifying a significant up-regulation of the resolvin and protectin pathway compared with normal gut tissue. Systemic treatment with protectin (PD)1_{n-3 DPA} o

SUBMITTER: Gobbetti T 

PROVIDER: S-EPMC5393238 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature