Prediction of changes in bone mineral density in postmenopausal women treated with once-weekly bisphosphonates.

ABSTRACT:

Background

In clinical practice, bone mineral density (BMD) determined by dual-energy x-ray absorptiometry is used to monitor response to osteoporosis therapy. However, 1 to 2 yr are usually required to assess patients' BMD responses. The possibility of earlier indicators of a response or nonresponse to treatment, such as changes in bone turnover markers (BTMs), is of interest to physicians and patients.

Methods

In this post hoc analysis of women treated with once-weekly bisphosphonates, we examined the association of tertile percentage change from baseline in BTMs at 3 or 6 months and association of several baseline clinical characteristics with 24-month percentage change from baseline in BMD and with percentage of patients showing BMD nonresponse (defined as BMD loss at tw

SUBMITTER: Burnett-Bowie SM 

PROVIDER: S-EPMC5393373 | biostudies-literature | 2009 Apr

REPOSITORIES: biostudies-literature