In Vivo and in Vitro Proteome Analysis of Human Immunodeficiency Virus (HIV)-1-infected, Human CD4⁺ T Cells.

ABSTRACT: Host-directed therapies against HIV-1 are thought to be critical for long term containment of the HIV-1 pandemic but remain elusive. Because HIV-1 infects and manipulates important effectors of both the innate and adaptive immune system, identifying modulations of the host cell systems in humans during HIV-1 infection may be crucial for the development of immune based therapies. Here, we quantified the changes of the proteome in human CD4⁺ T cells upon HIV-1 infection, both in vitro and in vivo A SWATH-MS approach was used to measure the proteome of human primary CD4⁺ T cells infected with HIV-1 in vitro as well as CD4⁺ T cells from HIV-1-infected patients with paired samples on and off antiretroviral treatment. In the in vitro e

SUBMITTER: Nemeth J 

PROVIDER: S-EPMC5393404 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature